Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). Quality Control of 109-12-6.
Wang, Chang-An;Rahman, Mahbubur Md.;Bisz, Elwira;Dziuk, Blazej;Szostak, Roman;Szostak, Michal research published 《 Palladium-NHC (NHC = N-heterocyclic Carbene)-Catalyzed Suzuki-Miyaura Cross-Coupling of Alkyl Amides》, the research content is summarized as follows. The Pd-catalyzed Suzuki-Miyaura cross-coupling of aliphatic amides I (R = t-Bu, Cy, nonyl, etc.) was reported. Although tremendous advances have been made in the cross-coupling of aromatic amide I (R = Ph), C-C bond formation from aliphatic amides I by selective N-C(O) cleavage has remained a major challenge. This longstanding problem in Pd catalysis has been addressed herein by a combination of (1) the discovery of N,N-pym/Boc amides I as a class of readily accessible amide-based reagents for cross-coupling and (2) steric tuning of well-defined Pd(II)-NHC catalysts for cross-coupling. The methodol. is effective for the cross-coupling of an array of 3°, 2°, and 1° aliphatic amide derivatives I. The catalyst system is user-friendly, since the catalysts are readily available and air- and bench-stable. Mechanistic studies strongly support an amide bond twist and external nN → π*C=O/Ar delocalization as a unified enabling feature of N,N-pym/Boc amides I in selective N-C(O) bond activation. The method provides a rare example of Pd-NHC-catalyzed cross-coupling of aliphatic acyl amide electrophiles I.
109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Quality Control of 109-12-6
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia