On June 11, 2007, Harbottle, Gareth W.; Feeder, Neil; Gibson, Karl R.; Glossop, Mel; Maw, Graham N.; Million, William A.; Morel, Florence F.; Osborne, Simon; Poinsard, Cedric published an article.Application In Synthesis of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine The title of the article was Microwave-assisted synthesis of mGluR1 ligands: carbon, nitrogen, and oxygen linked derivatives of pyrido[3,4-d]pyrimidin-4-ylamines. And the article contained the following:
The syntheses of 6-fluoropyrido[3,4-d]pyrimidin-4-ylamine derivatives is reported herein. Methods for generating C-, N-, and O-linked analogs by subsequent nucleophilic aromatic substitution of fluoride with alcs. or amines under microwave irradiation are described. The experimental process involved the reaction of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine(cas: 175357-98-9).Application In Synthesis of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine
The Article related to pyridopyrimidinylamine mglur1 ligand preparation, fluoropyridopyrimidinylamine amine nucleophilic aromatic substitution, alc fluoropyridopyrimidinylamine nucleophilic aromatic substitution and other aspects.Application In Synthesis of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia