Brumfitt, W.; Hamilton-Miller, J. M. T.; Grey, Daphne published an article in 1977, the title of the article was Antibacterial activity of combinations of clindamycin and antifolate agents.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate And the article contains the following content:
The antibacterial activities of clindamycin-HCl (I-HCl) [21462-39-5] in combination with the folate antagonists trimethoprim lactate [23256-42-0] or sulfamethoxazole [723-46-6] were only additive, suggesting that I is not an antifolate agent. Thus, some other mechanism of action must be responsible for the therapeutic effects of I against malaria and toxoplasmosis, conditions known to be susceptible to treatment with antifolate compounds Inhibition of protein synthesis is the most likely explanation for the action of I, but other antibiotics which inhibit bacterial protein synthesis have generally shown little activity against malaria. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
The Article related to clindamycin bactericidal action, trimethoprim clindamycin bactericidal activity, sulfamethoxazole clindamycin bactericidal activity, folate antagonist clindamycin bacteria and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia