Marhold, Albrecht et al. published their patent in 2010 |CAS: 785777-98-2

The Article related to polyfluoropyrazine preparation fluorination, polyfluoropyrimidine preparation fluorination, polyfluoropyridazine preparation fluorination, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Computed Properties of 785777-98-2

On August 4, 2010, Marhold, Albrecht; Ebenbeck, Wolfgang; Knauer, Stephan published a patent.Computed Properties of 785777-98-2 The title of the patent was Preparation of polyfluoro-N-heteroaromatics. And the patent contained the following:

A process for the preparation of title compounds I [X = N-heteroaromatic with provisos; A = fluoroalkyl, fluoroalkoxy, fluoroalkylthio; R1 = (R1′)n; R1′ = alkyl, aryl, arylalkyl; n = 0-1; Y = (Y’)m; Y’ = Cl, Br, F; m = 1-3] was disclosed. For example, HF/Autoclave(150°C) mediated fluorination of 2,4-dichloro-5-trichloropyrimidine afforded claimed polyfluoro-N-heteroaromatic II in 68% yield. The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).Computed Properties of 785777-98-2

The Article related to polyfluoropyrazine preparation fluorination, polyfluoropyrimidine preparation fluorination, polyfluoropyridazine preparation fluorination, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Computed Properties of 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia