On February 6, 2014, Bono, Ayako; Matsuda, Daisuke; Otake, Kenichi; Kakinuma, Hiroyuki; Kobashi, Yohei; Kawamura, Madoka; Shiozawa, Fumiyasu; Shimizu, Yuki; Kawabe, Kenichi; Hamada, Makoto published a patent.Computed Properties of 596114-50-0 The title of the patent was Hypoglycemic agents containing condensed heterocyclic compounds as GPR119 agonists. And the patent contained the following:
Hypoglycemic agents contain condensed heterocyclic compounds I [A = (un)substituted Ph or 5-6 membered heteroaryl; W = bond, O, NH, OCH2, CH2O; X = N, CR21; Y1 = N, CR22; Y2 = N, CR23; Y3 = N, CR24; R21-R24 = H, C1-6 alkyl; B = (un)substituted C2-6 alkyl, C3-8 cycloalkyl, (C3-8 cycloalkyl)C1-6 alkyl, (aryl)C1-6 alkyl, (saturated heterocyclyl)C1-6 alkyl, COOR31, 5-6 membered heteroaryl; R31 = C1-6 alkyl, C3-8 cycloalkyl, etc.] or their pharmaceutically acceptable salts as active ingredients and are useful for prevention and treatment of diabetes mellitus. Thus, tert-Bu 4-[5-[4-(methylsulfonyl)phenyl]-1H-indazol-1-yl]piperidine-1-carboxylate, prepared by several steps, promoted cellular cAMP production in human GPR119-expressing cells with ED50 of 31 nM. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Computed Properties of 596114-50-0
The Article related to condensed heterocycle preparation hypoglycemic gpr119 agonist antidiabetic, indazolylpiperidinecarboxylate preparation hypoglycemic gpr119 agonist antidiabetic, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Computed Properties of 596114-50-0
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia