On June 6, 2019, Chafeev, Mikhail published a patent.Product Details of 596114-50-0 The title of the patent was Preparation of compounds containing polysubstituted benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide or benzo[d][1,3]oxathiole 3,3-dioxide and uses thereof as agonists of G protein-coupled receptor 119. And the patent contained the following:
The title compounds I [X1 and X2 are selected from certain combinations of O, S, SO and SO2; X3 = CH, CF, N; X4 = (independently) CH or N; X6, X61 and X62 = (independently) H, halo, alkyl, etc.; X7 and X71 = H, halo, alkyl, etc.; or both X7 and X71, together form a cycloalkyl or heterocycle; A = (un)substituted alkoxy, piperazinyl and pyrrolidinyl] or enantiomers, diastereomers, hydrates, solvates, or pharmaceutically acceptable salts of I, or prodrugs or complexes thereof, useful in treating diseases and conditions associated with GPR119 dysregulation, type 2 diabetes mellitus, and related metabolic disorders, were prepared E.g., a multi-step synthesis of II, starting from 1-tert-butylpiperidine-4-one and trimethylsilyldiazomethane, was described. The potency of exemplified compounds I as GPR119 receptor agonists was assessed (data given). Also provided are compositions comprising compounds I. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Product Details of 596114-50-0
The Article related to benzooxathiole oxide preparation gpr119 agonist antidiabetic, diabetes mellitus type 2 metabolic disorder benzooxathiole oxide preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Product Details of 596114-50-0
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia