On July 31, 2014, Rudrapal, M.; Babu, T. Mariya; Chandra, T. Ravi; Durga, U. Divya; Swathi, V.; Usha Naga Chandrika, B.; Ravishankar, K. published an article.Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Synthesis and evaluation of heterocyclic scaffold-based styrene conjugates as new antibacterial agents. And the article contained the following:
The conjugation of different substituted styryl (-CH=CH-Aryl) moieties with the biol. relevant heteroaromatic scaffolds such as 4-benzylidene-2-methyloxazol-5-one, 3-methyl-1-phenylpyrazol-5-one, 2-methylbenzimidazole, 6-methyluracil afforded the newer series (four different series), I, II, III, IV [R = H, p-Cl, p-OCH3] of styrene derivatives and their antibacterial effectiveness was tested against both Gram-pos. and Gram-neg. bacteria by in-vitro agar well diffusion method (zone of inhibition in mm) and also by the determination of min. inhibitory concentration (MIC in μg/mL). The results of the antibacterial activity study reveal that the synthesized compounds I, II, III and IV possess in-vitro activity against the tested bacterial strains, which, however, was comparatively very less than that of the standard drug, amikacin sulfate. The structure-activity relationship study could be attributed that the overall antibacterial efficacy of the conjugated series of styrene derivatives I, II, III and IV is the sum of bio-effectiveness of styryl moieties and heterocyclic scaffolds. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione
The Article related to styrene benzimidazole oxazole pyrazole uracil preparation antibacterial structure activity, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia