On October 16, 2002, Bhattacharya, Samit Kumar; Kath, John Charles; Morris, Joel published a patent.Category: pyrimidines The title of the patent was Preparation of substituted bicyclo[]-4-amino-pyridopyrimidine derivatives as kinase inhibitors. And the patent contained the following:
Title compounds I [R1-2 = H, alkyl; R3 = (CR1R2)mR4; m = 0-6 or NR1R3 = (CR1R2)n-indol(in)yl; n = 0-2; X = N and Y is CR9 or X = CR9 and Y = N; R9 = fused-ring bicyclic, bridged bicyclic or spirobicylic group] were prepared For instance, 4-chloro-6-fluoropyrido[3,4-d]pyrimidine (preparation given) was reacted with [3-methyl-4-(pyridin-3-yloxy)phenyl]amine (t-BuOH/ClCH2CH2Cl, reflux, 1 h) and the product coupled to (3-azabicyclo[3.1.0]hex-6-yl)carbamic acid tert-Bu ester (EtOH, sealed tube, 105°, 24 h) and finally deprotected to give II. Selected compounds of the invention had IC50 in the range of 1 nM to 1 pM for erbB-2 receptor kinase. I are used for the treatment of hyperproliferative disorders. The experimental process involved the reaction of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine(cas: 175357-98-9).Category: pyrimidines
The Article related to bicyclic amino pyridopyrimidine erbb2 kinase inhibitor preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia