On July 24, 1997, Showalter, Howard Daniel Hollis; Winter, Roy Thomas; Rewcastle, Gordon William; Denny, William Alexander published a patent.Application of 175357-98-9 The title of the patent was Improved process for preparing 4,6-disubstituted pyrido[3,4-d]pyrimidines. And the patent contained the following:
The title compounds [I; R = aryl, alkyl, arylalkyl; R1, R2 = H, alkyl, hydroxyalkyl, etc.; R1R2 = 5-6 membered ring] were prepared Thus, reaction of 5-amino-2-fluoropyridine with di-tert-Bu dicarbonate followed by treatment of the resulting 5-[N-(tert-butoxycarbonyl)amino]-2-fluoropyridine with CO2, deprotection of 5-[N-(tert-butoxycarbonyl)amino]-2-fluoropyridine-4-carboxylic acid with CF3CO2H, reaction of 5-amino-2-fluoropyridine-4-carboxylic acid with formamidine acetate, treatment of 6-fluoropyrido[3,4-d]pyrimidin-4(3H)-one with SOCl2, reaction of 4-chloro-6-fluoropyrido[3,4-d]pyrimidine with 3-bromoaniline, and reaction of 4-[(3-bromophenyl)amino]-6-fluoropyrido[3,4-d]pyrimidine with MeNH2 afforded I [R = 3-BrC6H4; R1 = H; R2 = Me]. The experimental process involved the reaction of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine(cas: 175357-98-9).Application of 175357-98-9
The Article related to pyridopyrimidine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 175357-98-9
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia