On March 14, 2013, Nagase, Hiroshi; Fujii, Hideaki; Nakata, Eriko; Watanabe, Yoshikazu; Takahashi, Toshihiro published a patent.HPLC of Formula: 596114-50-0 The title of the patent was Preparation of morphinan derivatives as opioid δ receptor agonists. And the patent contained the following:
Title compounds I [R1 = H, alkyl, aryl, etc.; R2 = H, alkyl, cycloalkyl, etc.; R3-R5 = independently H, hydroxy, halo, etc.; R6a, R6b = independently H, F or hydroxy; R6a and R6b may combine to form oxo; R7, R8 = independently H, F or hydroxy; R9, R10 = independently H, alkyl, aryl, etc.; X = O or CH2; Y = C:O, C:S, SO2, etc.; or pharmacol. acceptable salts thereof] were prepared For example, reaction of (1S,3aS,5aS,6R,11bR,11cR)-3-benzyl-14-(cyclopropylmethyl)-3a,11-dihydroxy-10-methoxy-1,3,3a,4,5,6,7,11c-octahydro-2H-6,11b-(iminoethano)-1,5a-expoxynaphtho[1,2-e]indol-2-one with BH3·THF, treatment with PhBr/K2CO3/Cu, exposure to ethylenediamine/sodium silica-gel (stage I), debenzylation, benzoylation, and demethylation using BBr3 afforded compound II. In opioid receptor agonist activity test, the selected invention compounds, e.g., II, showed EC50 of <1 nM for opioid δ receptor. Compounds I are claimed useful for the treatment of pain. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).HPLC of Formula: 596114-50-0
The Article related to morphinan preparation opioid delta receptor agonist, analgesic morphinan opioid delta receptor agonist, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.HPLC of Formula: 596114-50-0
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia