On January 14, 2010, Bertram, Lisa Sarah; Fyfe, Matthew Colin Thor; Jeevaratnam, Revathy Perpetua; Keily, John; Krulle, Thomas Martin; Rasamison, Chrystelle Marie; Sambrook-Smith, Colin Peter; Swain, Simon Andrew published a patent.Related Products of 596114-50-0 The title of the patent was Piperidinyl compounds as GPCR agonists and their preparation, and use in the treatment of diabetes and obesity. And the patent contained the following:
The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of diabetes and obesity. Compounds of formula I wherein Q is CH and N; one of W, Y and Z is N and CH and the others are CR5; R1 is SO2Me and CONH2 and derivatives; R2, R3 and R4 are independently H and Me; n is 0, 1, and 2; R5 is C1-4 alkyl, C1-4 alkoxy, F, Cl, C1-3 fluoroalkyl and Bn; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their GPCR agonistic activity (some data given). The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Related Products of 596114-50-0
The Article related to piperidinyl compound preparation gpcr agonist treatment diabetes obesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Related Products of 596114-50-0
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia