Hamilton-Miller, J. M. T.; Grey, Daphne published an article in 1975, the title of the article was Resistance to trimethoprim in klebsiellae isolated before its introduction.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate And the article contains the following content:
In vitro 6 of 12 strains of Klebsiella aerogenes or K. ozaenae were resistant to trimethoprim lactate (I lactate) [23256-42-0], whereas all 12 strains were resistant to sulfamethoxazole [723-46-6]. All of these 12 strains were isolated and freeze-dried (1961-64) prior to clin. use of I. Of the 6 I-resistant strains, 5 were also resistant to tetracycline, chloramphenicol, and streptomycin. No evidence was found for R-factor involvement in I resistance. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
The Article related to trimethoprim resistance klebsiella, sulfamethoxazole resistance klebsiella, Biochemical Interactions: Microbial Systems and other aspects.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia