Fitriana, Adita Silvia; Royani, Sri published an article in 2022, the title of the article was Molecular docking study of chalcone derivatives as potential inhibitors of sars-cov-2 main protease.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:
SARS-CoV-2 main protease is a potential target for the development of AntiCOVID-19. Several chalcones have inhibitory activity against 3CLpro SARSCoV and 3CLpro MERS-CoV. This study aims to predict the potential of chalcones in inhibiting 3CLproSARS-CoV-2, which plays a role in the viral replication process. In silico research carried the prediction through mol. docking toward proteins with PDB ID 6LU7 and 6Y2F. Compound K27 has a docking score more neg. than lopinavir. This result indicates that compound K27 is predicted to inhibit the SARS-CoV-2 replication. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione
The Article related to chalcone inhibitor protease mol docking sars cov2, Pharmacology: Effects Of Gastrointestinal and Respiratory Drugs and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia