On June 16, 1980, Quintanilla Almacro, Eliseo published a patent.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Trimethoprim lactate. And the patent contained the following:
The title compound (I lactate) [23256-42-0] was prepared by addition of lactic acid in CHCl3 to the free base to increase the bioavailability of I, for example, from suppositories. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
The Article related to trimethoprim lactate, Pharmaceuticals: Formulation and Compounding and other aspects.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia