Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine. A new synthetic method of this compound is introduced below., 1004-40-6
General procedure: A mixture of freshly calcined K2CO3 (7.4 mmol), 2-thiouracil 2a-c (7.0 mmol), 2-(bromomethyl)-2-isoindole-1,3-dione (7.7 mmol), and anhydrous DMF (20 ml) was stirred at room temperature for 72 h. The reaction mixture was filtered, and the filtrate was evaporated to dryness. The obtained residue was taken up in 1 aqueous solution, the mixture was filtered, the filtrate was extracted with EtOAc (3¡Á50 ml), dried over MgSO4, filtered, and evaporated at reduced pressure. The solids collected by filtration were air-dried until constant mass, combined with the evaporated organic extract, and the obtained mixture was purified by preparative HPLC.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1004-40-6, 6-Amino-4-hydroxy-2-mercaptopyrimidine, and friends who are interested can also refer to it.
Reference:
Article; Novakov, Ivan A.; Sheikin, Dmitry S.; Chapurkin, Viktor V.; Nawrozkij, Maksim B.; Babushkin, Alexande S.; Kuznetsov, Yaroslav P.; Ruchko, Evsey A.; Kachala, Vadim V.; Maryshev, Anton Yu.; Schols, Dominique; Chemistry of Heterocyclic Compounds; vol. 56; 1; (2020); p. 67 – 72; Khim. Geterotsikl. Soedin.; vol. 56; 1; (2020); p. 67 – 72,6;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia