Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus was written by Coen, Donald M.; Fleming, H. Edward Jr.; Leslie, Laurel K.; Retondo, Margaret J.. And the article was included in Journal of Virology on February 28,1985.Electric Literature of C10H13FN2O5 The following contents are mentioned in the article:
Seven herpes simplex virus mutants which have been previously shown to be resistant to arabinosyladenine [5536-17-4] were examined for their sensitivities to 4 types of antiviral drugs. These drugs were a pyrophosphate analog, 4 nucleoside analogs altered in their sugar moieties, 2 nucleoside analogs altered in their base moieties, and 1 altered in both. The 7 mutants exhibited 5 distinct phenotypes based on their sensitivities to the drugs relative to wild-type strain KOS. All mutants exhibited resistance to acyclovir [59277-89-3] and arabinosylthymine [605-23-2], as well as marginal resistance to iododeoxyuridine [54-42-2], whereas all but one exhibited resistance to phosphonoformic acid [4428-95-9]. The mutants exhibited either sensitivity or hypersensitivity to the other drugs tested, 2′-nor-deoxyguanosine [82410-32-0], 5-methyl-2′-fluoroarauracil [69256-17-3], 5-iodo-2′-fluoroarauracil [69123-98-4], and bromovinyldeoxyuridine [82768-44-3], some of which differed only slightly from drugs to which the mutants were resistant. These results suggest ways to detect and treat arabinosyladenine-resistant isolates in the clinic. Antiviral hypersensitivity was a common phenotype. Mutations conferring hypersensitivity to 2′-nor-deoxyguanosine in mutant PAAr5 and to bromovinyldeoxyridine in mutant tsD9 were mapped to nonoverlapping regions of 1.1 and 0.8 kilobase pairs, resp., within the herpes simplex virus DNA polymerase [9012-90-2] locus. Thus, viral DNA polymerase mediates sensitivity to these 2 drugs. However, reports of mutations in the DNA polymerase locus conferring resistance to these 2 drugs could not be confirmed. All of the mutants exhibited altered sensitivity to ≥2 types of drugs, suggesting that single mutations affect recognition of the base, sugar, and triphosphate moieties of nucleoside triphosphates by viral polymerase. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Electric Literature of C10H13FN2O5).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Electric Literature of C10H13FN2O5
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3