Activities of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2 was written by Schinazi, Raymond F.; Fox, Jack J.; Watanabe, Kyoichi A.; Nahmias, Andre J.. And the article was included in Antimicrobial Agents and Chemotherapy on January 31,1986.Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one The following contents are mentioned in the article:
As measured by plaque and yield reduction assays, several metabolites of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) were highly active against herpes simplex virus types 1 and 2. These metabolites included the 2′-deoxy-2′-fluoroarabinosyl derivatives of 5-iodouracil, cytosine, uracil, and thymine. In mice inoculated intracerebrally with herpes simplex virus type 2, the relative order of potency of these compounds and known antiviral drugs were as follows: 2′-fluoro-5-methylarabinosyluracil (FMAU) [69256-17-3] ≫ 2′-fluoro-5-iodoarabinosylcytosine (FIAC) [69123-90-6] ≈ 2′-fluoro-5-iodoarabinosyluracil (FIAU) [69123-98-4] > acyclovir ≈ vidarabine ≫ 2′-fluoroarabinosylcytosine (FAC) [56632-83-8] ≈ 2′-fluoroarabinosyluracil (FAU) [69123-94-0]. One of the main metabolites of FMAU, 2′-fluoro-5-hydroxymethylarabinosyluracil [94817-51-3], was essentially inactive in vivo. FIAC-, FIAU-, FMAU-, FAC-, and FAU-resistant herpes simplex virus variants prepared in cell culture were found to be (i) devoid of viral thymidine kinase [9002-06-6], (ii) cross-resistant to one another and resistant to drugs requiring viral thymidine kinase for activation, and (iii) sensitive to vidarabine or phosphonoformate. These results indicate that FIAC, FIAU, and FMAU require the virally encoded thymidine kinase for activation and suggest that the antiviral activity of FAU and FAC in cell cultures is also mediated by this enzyme. The interaction of the fluoroarabinosylpyrimidine nucleosides with herpes simplex virus thymidine kinase in a cell-free system is also described. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one).
4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8