Riadi, Yassine published the artcileMicrowave Irradiation-Mediated Synthesis of New Substituted Pyridopyrimidines via the Suzuki-Miyaura Coupling Reaction and Biological Evaluation, Safety of Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate, the main research area is pyridopyrimidine preparation antibacterial.
An eco-friendly, effective and easy route to synthesize substituted pyridopyrimidines I [Ar = Ph, 3-MeC6H4, 4-pyridyl, etc.] was reported starting from 4-methylsulfanylpyrido[3,2-d]pyrimidines that undergo a SuzukiMiyaura coupling reaction under microwave irradiation Initially, the chlorinated intermediate was prepared from the available chem. reagents. The prepared compounds were effectively synthesized by reacting the chlorinated intermediate with versatile boronic acids. The resulting products were tested for their antimicrobial efficiency against different microbes. In this way, three synthesized derivatives were found to be active against the studied bacterial strains. Unfortunately, the derivatives were found to be inactive against the studied fungus.
Polycyclic Aromatic Compounds published new progress about Antibacterial agents. 74840-38-3 belongs to class pyrimidines, name is Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate, and the molecular formula is C8H9BrN2O2S, Safety of Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia