Ku, Therese published the artcileSynthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1, Related Products of pyrimidines, the main research area is fleximer bipyrimidine synthesis antiHIV HIV1 nucleocapsid protein; Fleximers; HIV-1; NC; Pyrimidine; Synthesis.
Anti-HIV-1 drug design has been notably challenging due to the virus’ ability to mutate and develop immunity against com. available drugs. The aims of this project were to develop a series of fleximer base analogs that not only possess inherent flexibility that can remain active when faced with binding site mutations, but also target a non-canonical, highly conserved target: the nucleocapsid protein of HIV (NC). The compounds were predicted by computational studies not to function via zinc ejection, which would endow them with significant advantages over non-specific and thus toxic zinc-ejectors. The target fleximer bases were synthesized using palladium-catalyzed cross-coupling techniques and subsequently tested against NC and HIV-1. The results of those studies are described herein.
Bioorganic & Medicinal Chemistry published new progress about Anti-HIV agents. 36847-11-7 belongs to class pyrimidines, name is 2,4,6-Tribromopyrimidine, and the molecular formula is C4HBr3N2, Related Products of pyrimidines.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia