Panciera, Michele published the artcileInduced α,γ-cyclic peptide rotodimer recognition by nucleobase scaffolds, Recommanded Product: 2-(4-((tert-Butoxycarbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetic acid, the publication is Peptide Science (Hoboken, NJ, United States) (2020), 112(1), e24132, database is CAplus.
The β-sheet-type structures derived from the stacking of α,γ-cyclic peptides to form peptides nanotubes can provide different topoisomers, nonequivalent cyclic peptide stacks generated by the relative rotation through the channel axis of one cyclic peptide with respect to the next component. This rotation generates a series of cyclic peptide dimers paired by the same type of hydrogen bond pattern but differentiated by the cross-strand side chain-side chain pairwise. The control of this peptide-peptide relative orientation in stacked supramol. aggregates is required for practical applications in material sciences, sensing, or biol. We propose the use of small oligonucleotides to control the prevalence of a particular dimer through the formation of specific hydrogen bonds between cyclic peptides bearing a nucleobase attached to a serine side chain with a complementary oligonucleotide (peptide nucleic acid).
Peptide Science (Hoboken, NJ, United States) published new progress about 172405-16-2. 172405-16-2 belongs to pyrimidines, auxiliary class Pyrimidine,Carboxylic acid,Amine,Amide, name is 2-(4-((tert-Butoxycarbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetic acid, and the molecular formula is C11H15N3O5, Recommanded Product: 2-(4-((tert-Butoxycarbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetic acid.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia