Huang, Kuo-Ting published the artcileCombinatorial Self-Assembly of Glycan Fragments into Microarrays, COA of Formula: C26H26N4O7, the publication is ChemBioChem (2011), 12(1), 56-60, database is CAplus and MEDLINE.
We have demonstrated that complex glycan arrays can be accessed through the combinatorial self assembly of PNA-encoded carbohydrate fragments. Although the use of DNA microarrays to sort carbohydrate-DNA conjugates had previously been reported, previous efforts were restricted to monosaccharides and did not explore a broad range of glycan structures, nor their combinatorial assembly. The cooperativity of the fragments in their interaction with carbohydrate-binding proteins was demonstrated with two different lectins. The binding profile showed the strongest interaction for discrete combinations of two fragments. Importantly, the PNA-tagged glycans can be readily prepared from native oligosaccharides obtained from natural or com. sources by conversion of the anomeric position into a thiol on a mg scale by a two- to three-step process. The simplicity of the protocols described should make glycan arrays more broadly accessible. Immobilization of glycans by hybridization offers a reliable approach by which to obtain a homogeneous distribution of ligands within a microarray spot and allows the use of microarrays with higher d. than accessible by contact printing, which is currently the standard practice. Last but not least, combinatorial self assembly of fragments on DNA microarrays should be broadly applicable beyond the glycan fragments described here.
ChemBioChem published new progress about 169396-92-3. 169396-92-3 belongs to pyrimidines, auxiliary class Pyrimidine,Carboxylic acid,Amine,Amide,Others,PNA, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid, and the molecular formula is C26H26N4O7, COA of Formula: C26H26N4O7.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia