Synthesis in the heterocyclic series. IX. Syntheses and reactions of 4,6-disubstituted pyrimidine-5-aldehydes was written by Bredereck, Hellmut;Simchen, Gerhard;Santos, Antonio A.. And the article was included in Chemische Berichte in 1967.HPLC of Formula: 14160-85-1 The following contents are mentioned in the article:
cf. CA 66, 94992n. In the reactions of dihydroxypyrimidines with Vilsmeier reagents, uracil gave (Me2N+:CHNHCOCH:CHOH)Cl-, and 4-hydroxy-6-oxodihydropyrimidines (I, R = H, Me, or Ph) were formylated at their 5-position to give 4-hydroxy-6-oxo-5-dimethylaminomethylene-5,6-dihydropyrimidine-HCl derivatives (II) which were converted, by POCl3/PhNMe2, into 4,6-dichloro-5-formylpyrimidine derivatives (III). III were converted, by nucleophilic agents (RR’NH or MeNH2), into 4-amino-6-chloro-5-formylpyrimidine derivatives (IV, R = H, Me, or Ph, R’ = H or Me) or 4,6-bis(methylamino)-5-methylaminomethylenepyrimidine. II were treated with Et malonate to give 7H-pyrano[2,3-d]pyrimidine derivatives (V). This study involved multiple reactions and reactants, such as 4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1HPLC of Formula: 14160-85-1).
4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.HPLC of Formula: 14160-85-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia