Syntheses in the heterocyclic series. XVII. Syntheses and reactions of pyrimidine-5-carboxaldehydes was written by Bredereck, Hellmut;Simchen, Gerhard;Wagner, Hans;Santos, Antonio A.. And the article was included in Justus Liebigs Annalen der Chemie in 1972.Application of 14160-85-1 The following contents are mentioned in the article:
Formylation of the pyrimidines I (R = H, Me, or Ph; X = H) with MeN:+CHCl Cl- gave I [X = CH:N+Me2 Cl- (II)]. Reaction of II with H2O, PhNHNH2, MeNH2, POCl3, or NaCH(CO2Et)2 gave the aldehydes I (X = CHO), the hydrazones I (X = CH:NNHPh), the imines I (X = CH:NMe), the dichloro derivatives III, or the pyrones IV, resp. Hydrogenation of III (R = H) over Pd-C and MgO gave 84% pyrimidine-5-carboxaldehyde, which can undergo most of the aldehyde reactions under mild conditions. This study involved multiple reactions and reactants, such as 4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1Application of 14160-85-1).
4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Application of 14160-85-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia