Inhibition of demethylases by GSK-J1/J4 was written by Kruidenier, Laurens;Chung, Chun-wa;Cheng, Zhongjun;Liddle, John;Che, KaHing;Joberty, Gerard;Bantscheff, Marcus;Bountra, Chas;Bridges, Angela;Diallo, Hawa;Eberhard, Dirk;Hutchinson, Sue;Jones, Emma;Katso, Roy;Leveridge, Melanie;Mander, Palwinder K.;Mosley, Julie;Ramirez-Molina, Cesar;Rowland, Paul;Schofield, Christopher J.;Sheppard, Robert J.;Smith, Julia E.;Swales, Catherine;Tanner, Robert;Thomas, Pamela;Tumber, Anthony;Drewes, Gerard;Oppermann, Udo;Patel, Dinshaw J.;Lee, Kevin;Wilson, David M.. And the article was included in Nature (London, United Kingdom) in 2014.Computed Properties of C24H27N5O2 The following contents are mentioned in the article:
Our result sshow that GSK-J1 and GSK-J4 inhibit demethylases in addition to KDM6B and KDM6A. Therefore,this compound can not be used alone for demonstrating a role for H3K27 demethylationin biol. processes. This study involved multiple reactions and reactants, such as Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate (cas: 1373423-53-0Computed Properties of C24H27N5O2).
Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate (cas: 1373423-53-0) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Computed Properties of C24H27N5O2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia