Pizzirani, Daniela published the artcileDiscovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR), Product Details of C5H6N2O2, the publication is Journal of Medicinal Chemistry (2013), 56(9), 3518-3530, database is CAplus and MEDLINE.
1-(Alkylamino)-2,4-pyrimidinediones such as I [R = H, F, MeO, F3C, Ph; R1 = Me(CH2)nNH; R2 = H, Me, MeO2C; n = 5, 7] were prepared as inhibitors of acid ceramidase for potential use as antitumor agents. Uracils bearing an electron-withdrawing substituent at position 5, a substituent such as Me at position 3, and an alkylaminocarbonyl moiety with a six- to eight-carbon alkyl group at position 1 were the most effective inhibitors of acid ceramidase of the compounds tested. The acid ceramidase inhibition and stability of an alkylaminopyrimidinedione was correlated with the stabilization of the antibonding orbital of its N1-carbonyl bond. I (R = H, F, Ph; R2 = H, Me; n = 5, 7) inhibited a human cancer cell line (SW403) with IC50 values of 20-24 μM. I (R = F, F3C, MeO; R2 = H, MeO2C; n = 5, 7) inhibited acid ceramidase with single digit-nanomolar IC50 values (IC50 = 4-7 nM).
Journal of Medicinal Chemistry published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Product Details of C5H6N2O2.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia