Design and synthesis of 1,2,3-triazole incorporated pyrimidine-benzoxazole derivatives as anticancer agents was written by Sudhakar, D. G. S.;Rao, A. Srinivasa;Reddy, Ch. Venkata Ramana;Somaiah, Nalla. And the article was included in Chemical Data Collections in 2022.COA of Formula: C6H4N2 This article mentions the following:
A new library of 1,2,3-triazole linked pyrimidine-benzoxazole derivatives I [Ar = pyridin-4-yl, 4-ClC6H4, pyrimidin-2-yl, etc.] was synthesized and characterized. Further, the preliminary anticancer activities of compounds I were tested on four human cancer cell lines such as prostate cancer (PC3 and DU-145), lung cancer (A549) and breast cancer (MCF-7) by using of MTT method. These activities were compared with clin. drug candidate etoposide. Among the screened compounds, five compounds I [R = pyridin-4-yl, pyrimidin-2-yl, 3,5-(Me)2C6H3, 3,5-(OMe)2C6H3, 3,4,5-(OMe)3C6H2] exhibited considerable activities on four cell lines. In which one compound I [R = pyrimidin-2-yl] showed most promising activity among the synthesized compounds In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0COA of Formula: C6H4N2).
2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.COA of Formula: C6H4N2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia