Time-Efficient Synthesis of Pyrido[2,3-d]pyrimidinones via α-Oxoketenes was written by Castillo, Juan-Carlos;Quiroga, Jairo;Rodriguez, Jean;Coquerel, Yoann. And the article was included in European Journal of Organic Chemistry in 2016.Product Details of 54030-56-7 This article mentions the following:
α-Oxoketene reactive intermediates generated in situ by microwave-assisted Wolff rearrangement of 2-diazo-1,3-dicarbonyl compounds have been found to react with 6-aminopyrimidine derivatives as 1,3-C,N-bis-nucleophiles to yield pyrido[2,3-d]pyrimidinones and related compounds amenable to further functionalization. Thus, e.g., Friedel-Crafts/imination cascade reaction of 3-diazoacetylacetone with 6-amino-1,3-dimethyluracil under microwave radiation afforded pyridopyrimidinone I (98%). In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Product Details of 54030-56-7).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Product Details of 54030-56-7
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia