Application of 6554-61-6 , The common heterocyclic compound, 6554-61-6, name is 4,5-Dichloropyrimidine, molecular formula is C4H2Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
1- { 3- [2-methoxy-5 -nitro-4-(tetramethyl- 1,3 ,2-dioxaborolan-2-yl)phenoxy]propyl }pynolidine (500 mg, 1.23 mmol), 4,5-dichloropyrimidine (220 mg, 1.48 mmol), Pd(amphos)C12 (59 mg, 0.08 mmol) and 2M sodium carbonate (1.23 mL, 2.46 mmol) were combined in 1,4-dioxane (5 mL). The mixture was purged with N2 for 6 mm, sealed and left stifling at 90 C for 45 minutes. The mixture was cooled to room temperature, diluted with water and extracted with ethyl acetate. The combinedorganic layers were washed with water. After removal of the organic solvents under reduced pressure, the residue was purified by flash chromatography on silica gel column eluted with 0-100% solvent A in CH2C12 (solvent A: 0.2% NH4OH/10% MeOH/88.9%CH2C12) to provide the title compound as a brown solid (422 mg, 87%). MS (ESI, pos. ion) mlz: 393.0 (M+1).
The synthetic route of 6554-61-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; YU, Chul; YU, Ming; ZANCANELLA, Manuel; LI, Zhe; (202 pag.)WO2018/226998; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia