Pyrimidines. XIII. 2- and 6-Substituted 4-pyrimidinecarboxylic acids was written by Daves, G. Doyle Jr.;O’Brien, Darrell E.;Lewis, Leland R.;Cheng, C. C.. And the article was included in Journal of Heterocyclic Chemistry in 1964.Application In Synthesis of 2-Chloropyrimidine-4-carbonitrile This article mentions the following:
The abnormal behavior of 4,6-dimethyl-2-pyrimidinol towards HONO has been clarified. The reaction between 4-methyl-2-pyrimidinol and HONO has been utilized as a new synthetic procedure for the preparation of several 2-substituted 4-pyrimidinecarboxylic acids. 2-Hydroxy-4-pyrimidinecarboxylic acid has also been prepared from 4-chloro-2-methylthiopyrimidine via the trimethylammonium intermediate. 6-Amino-and 6-thio-4-pyrimidinecarboxylic acids have been readily prepared from the previously reported 6-hydroxy-4-pyrimidinecarboxylic acid. In the experiment, the researchers used many compounds, for example, 2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4Application In Synthesis of 2-Chloropyrimidine-4-carbonitrile).
2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Application In Synthesis of 2-Chloropyrimidine-4-carbonitrile
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia