An efficient synthesis of 4-chloro-2-pyrrolino[2,3-d]pyrimidin-6-one and its 7-substituted analogues was written by Vaid, Radhe K.;Spitler, Jeremy T.;Boini, Sathish;May, Scott A.;Hoying, Richard C.. And the article was included in Synthesis in 2012.Formula: C7H6Cl2N2O2 This article mentions the following:
An efficient synthesis of I [R = H] was achieved in four steps starting from di-Me malonate in 23% overall yield. This synthesis was demonstrated on 100 g scale to obtain I [R = H] in 98.5% purity. Similarly, I [R = 2,4-(MeO)2C6H3, PhCH(Me)] were synthesized by the reaction of Me 2-(4,6-dichloropyrimidin-5-yl)acetate with an appropriately substituted benzylamine. In the experiment, the researchers used many compounds, for example, Methyl 2-(4,6-dichloropyrimidin-5-yl)acetate (cas: 171096-33-6Formula: C7H6Cl2N2O2).
Methyl 2-(4,6-dichloropyrimidin-5-yl)acetate (cas: 171096-33-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Formula: C7H6Cl2N2O2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia