Microwave-assisted three-component synthesis and in vitro antifungal evaluation of 6-cyano-5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-ones was written by Quiroga, Jairo;Cisneros, Carlos;Insuasty, Braulio;Abonia, Rodrigo;Cruz, Silvia;Nogueras, Manuel;Manuel de la Torre, Jose;Sortino, Maximiliano;Zacchino, Susana. And the article was included in Journal of Heterocyclic Chemistry in 2006.Electric Literature of C6H9N3OS This article mentions the following:
The reaction of 6-aminopyrimidin-4-ones with benzaldehydes and β-iminobutyronitrile or benzoylacetonitrile under microwave irradiation in dry media yields 6-cyano-5,8-dihydropyrido[2,3-d]-pyrimidinones. The structure of the synthesized compounds was determined on the basis of NMR measurements, especially by 1H,1H-, 1H,13C COSY, DEPT, and NOESY experiments In contrast with other pyrido[2,3-d]pyrimidine derivatives, these compounds did not show any antifungal in vitro activity â?50 μg/mL. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Electric Literature of C6H9N3OS).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Electric Literature of C6H9N3OS
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia