Reactions of 6-aminopyrimidines with 2-dimethylaminomethylenetetralone. Regiospecific synthesis of 5,6-dihydrobenzo[h]pyrimido[4,5-b]quinolines was written by Quiroga, Jairo;Insuasty, Braulio;Insuasty, Henry;Abonia, Rodrigo;Ortiz, Antonio;Sanchez, Adolfo;Nogueras, Manuel. And the article was included in Journal of Heterocyclic Chemistry in 2001.Synthetic Route of C6H9N3OS This article mentions the following:
Benzo[h]pyrimido[4,5-b]quinolines, e.g. I (R = H, Me; X = MeO, MeS, NH2), were prepared via a regiospecific cyclocondensation reaction between 6-aminopyrimidines, e.g. II, and 2-dimethylaminomethylentetralone hydrochloride (III). The linear structures of the final compounds were determined by NMR measurements, especially by 1H, 1H-, 1H, 13C COSY and DEPT experiments In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Synthetic Route of C6H9N3OS).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Synthetic Route of C6H9N3OS
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia