Extracurricular laboratory: Synthetic route of HPLC of Formula: C5H4N2O2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,31519-62-7, 2-Pyrimidinecarboxylic acid, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.31519-62-7, name is 2-Pyrimidinecarboxylic acid, molecular formula is C5H4N2O2, molecular weight is 124.1, as common compound, the synthetic route is as follows.HPLC of Formula: C5H4N2O2

EXAMPLE 5E This example illustrates the esterification of a pyrimidine carboxylic acid to the corresponding carboxylic ester. Compound No. 82 (see Example 5D) (0.19 g) was added in methanolic hydrogen chloride (5 cm3 of a saturated solution) and the flask was stoppered and left to stand for 72 hours. All the solid starting material had dissolved. The solution was evaporated to dryness at reduced pressure and the residue was dissolved in ethyl acetate. The organic solution was washed with saturated aqueous sodium bicarbonate and dried over magnesium sulfate. Evaporation of solvent under reduced pressure gave an oil which was chromatographed on silica gel, eluding with 1:4 ethyl acetate:hexane to give methyl 2-[(4,4-difluoro-3-butenyl)thio]-4-pyrimidinecarboxylate (Compound No. 83) (0.154 g). M+ =260; 1 H NMR (CDCl3): delta2.40-2.54(2H m); 3.24(2H,t); 4.00(3H,s); 4.22-4.40(1H,m); 7.64(1H,d); 8.74(1H,d).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,31519-62-7, 2-Pyrimidinecarboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Zeneca Limited; US5684011; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia