Copper-catalyzed three-component formal [3+1+2] annulations for the synthesis of 2-aminopyrimidines from O-acyl ketoximes was written by Xu, Zhenhua;Chen, Hongbiao;Deng, Guo-Jun;Huang, Huawen. And the article was included in Organic & Biomolecular Chemistry in 2021.SDS of cas: 40230-24-8 This article mentions the following:
A copper-based catalytic system has been developed to enable formal [3+1+2] annulations of ketoxime acetates, e.g., 3,4-dihydronaphthalen-1(2H)-one O-acetyl oxime aldehydes, e.g., benzaldehyde and cyanamide. This protocol offers a new strategy for the synthesis of highly substituted 2-aminopyrimidine compounds e.g., I, and more importantly, pyrimidines have now been included in the N-heterocycle family constructed using O-acyl ketoximes as N-C-C synthons. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8SDS of cas: 40230-24-8).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.SDS of cas: 40230-24-8
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia