Rise, Frode et al. published their research in Journal of the Chemical Society in 1985 | CAS: 42748-90-3

5-Chloropyrimidin-2(1H)-one hydrochloride (cas: 42748-90-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Synthetic Route of C4H4Cl2N2O

Regioselectivity in the reactions of aryltriisopropoxytitanium with pyrimidinones was written by Rise, Frode;Undheim, Kjell. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1985.Synthetic Route of C4H4Cl2N2O This article mentions the following:

Complete regioselectivity was observed in the 1:1 condensation between 4-RC6H4Ti(OCHMe2)3 (R = H, Cl, OMe) and pyrimidin-2(1H)ones I (R1 = H; R2 = Me, CH2Ph, CH2OCH2Ph, CH2SC6H4Cl-4; R3 = H, Cl, Br, iodo). The new C-C bond was formed at C-4 to yield product II. Subsequent dehydrogenation with MnO2 or DDQ produced I (R1 = C6H4R). In the experiment, the researchers used many compounds, for example, 5-Chloropyrimidin-2(1H)-one hydrochloride (cas: 42748-90-3Synthetic Route of C4H4Cl2N2O).

5-Chloropyrimidin-2(1H)-one hydrochloride (cas: 42748-90-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Synthetic Route of C4H4Cl2N2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia