Gold-nanoparticle-based multiplex immuno-strip biosensor for simultaneous determination of 83 antibiotics was written by Lei, Xianlu;Xu, Xinxin;Liu, Liqiang;Xu, Liguang;Wang, Li;Kuang, Hua;Xu, Chuanlai. And the article was included in Nano Research.Computed Properties of C11H12N4O3S This article mentions the following:
Antibiotic residues, generated by the irrational use of drugs and environmental pollution, have always been a great challenge to aquaculture safety. Therefore, a quick, convenient, and performance-excellent way to detect antibiotic residues in aquaculture fish is urgently required. In this study, a multiplex immunochromatog. strip biosensor based on gold nanoparticles was developed for the simultaneous detection of five classes of antibiotic residues (24 β-lactam antibiotics, 26 sulfonamides, five tetracyclines, 24 quinolones, and four amphenicols) in aquaculture fish within 10 min. The detection ranges of five representative antibiotics, penicillin G, sulfamethazine, tetracycline, enrofloxacin, and chloramphenicol, were 2.33-38.4, 0.688-17.1, 1.4-48.1, 1.45-32.9, and 0.537-9.06 μg/kg, resp. The accuracy and stability of these measurements were demonstrated by analyzing spiked fish samples, with recovery rates of 87.5%-115.2% and a coefficient of variation < 9.5%. The cross-reaction rates, based on the five representative antibiotics, were 3.77%-202% for β-lactams, 3.95%-137% for sulfonamides, 9.19%-100% for tetracyclines, 4.9%-145% for quinolones, and 3.2%-100% for amphenicols. The excellent testing performance of the biosensor strip to most of antibiotic residues in aquaculture fish ensures they meet the maximum residue limits required by countries or organizations. Therefore, this multiplex immunochromatog. strip biosensor is potentially applicable to the rapidly on-site determination of antibiotic residues in aquaculture fish. [graphic not available: see fulltext] In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Computed Properties of C11H12N4O3S).
4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Computed Properties of C11H12N4O3S
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia