The preparation of some 4,6-disubstituted pyrimidine-5-carboxylic acids was written by Mehta, M. D.;Miller, D.. And the article was included in Journal of the Chemical Society in 1965.Computed Properties of C6H7BrN2O2 This article mentions the following:
4,6-Disubstituted pyrimidine-5-carboxylic acids have been prepared from 5-bromopyrimidines through the halogenmetal interconversion with n-butyllithium. When bromine and chlorine were both present in the pyrimidine nucleus, only the former underwent the interconversion reaction. Most of the acids were converted into derivatives through their acid chlorides. The reaction of 4,6-dimethoxypyrimidine with n-butyllithium gave a 2,5-dihydropyrimidine whose N.M.R. spectrum showed coupling between the C-2 and C-5 protons with the unusually large coupling constant of 5.5 c./s. This is discussed. In the experiment, the researchers used many compounds, for example, 5-Bromo-4,6-dimethoxypyrimidine (cas: 4319-77-1Computed Properties of C6H7BrN2O2).
5-Bromo-4,6-dimethoxypyrimidine (cas: 4319-77-1) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Computed Properties of C6H7BrN2O2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia