Synthesis, characterization of 4,6-disubstituted aminopyrimidines and their sulphonamide derivatives as anti-amoebic agents was written by Siddiqui, Shadab Miyan;Azam, Amir. And the article was included in Medicinal Chemistry Research in 2014.HPLC of Formula: 40230-24-8 This article mentions the following:
The present study describes the synthesis and anti-amoebic activity of 4,6-disubstituted aminopyrimidines and their sulfonamide derivatives (1-20). All the desired compounds were characterized by spectral data and their purity was confirmed by elemental anal. The aim of the study was to explore the effect of the target compounds on in vitro growth of HM1:IMSS strain of Entamoeba histolytica. In vitro anti-amoebic activity was performed by microdilution method and the results were compared with standard drug metronidazole. The results revealed that sulfonamide derivatives showed better activity than 4,6-disubstituted aminopyrimidines. 5 Pyrimidine and 12 sulfonamide derivatives were better inhibitors of the growth of E. histolytica than the reference drug metronidazole (IC50 = 1.80 μM). The promising in vitro anti-amoebic activity of the compounds make them promising mols. for further lead optimization in the development of novel anti-amoebic agents, therefore, it is hoped that these preliminary results could help in designing better mols. with an enhanced anti-amoebic activity. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8HPLC of Formula: 40230-24-8).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.HPLC of Formula: 40230-24-8
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia