Ag-Assisted Fluorination of Unprotected 4,6-Disubstituted 2-Aminopyrimidines with Selectfluor was written by Wang, Chenxi;Cai, Juewang;Zhang, Min;Zhao, Xiaoming. And the article was included in Journal of Organic Chemistry in 2017.COA of Formula: C16H13N3 This article mentions the following:
In the presence of Ag2CO3, arylpyrimidinamines I (R = Ph, 4-MeC6H4, 4-FC6H4; R1 = PhCH2, 4-MeC6H4CH2, 4-FC6H4CH2; R = R1 = Ph, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 3-ClC6H4, 4-MeC6H4, 2-thienyl; R2 = H) underwent regioselective fluorination with Selectfluor® in MeCN to yield 5-fluoro-2-pyrimidinamines I (R = Ph, 4-MeC6H4, 4-FC6H4; R1 = PhCH2, 4-MeC6H4CH2, 4-FC6H4CH2; R = R1 = Ph, 4-FC6H4,4-ClC6H4, 4-BrC6H4, 3-ClC6H4, 4-MeC6H4, 2-thienyl; R2 = F) in 44-72% yields. The structures of I (R = Ph; R1 = PhCH2; R2 = F), I (R = R1 = 2-thienyl; R2 = F), and of the tetrasilver perchlorate complex of I (R = R1 = Ph; R2 = H) with Ph2PCH2PPh2 were determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8COA of Formula: C16H13N3).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.COA of Formula: C16H13N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia