Heterocyclic polyfluoro compounds. X. Nucleophilic substitution in tetrafluoropyrimidine was written by Banks, Ronald E.;Field, D. S.;Haszeldine, Robert N.. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1967.SDS of cas: 17573-78-3 This article mentions the following:
Tetrafluoropyrimidine, prepared in high yield by reaction of tetrachloropyrimidine with anhydrous KF at elevated temperatures, is highly susceptible to attack by nucleophiles; the ease of displacement of ring fluorines decreases in the order 4- and 6- > 2- >> 5-. Through use of appropriate nucleophilic reagents the fluoropyrimidines I-III (Y = NH2, OMe, NHPh, NHMe, or NMe2), and IV (Z = OMe) were prepared The structures of these compounds were established by N.M.R. spectroscopy. Interpretation of the orientation of nucleophilic attack on tetrafluoropyrimidine and on pentafluoropyridine is provided. In the experiment, the researchers used many compounds, for example, 4,5,6-Trifluoropyrimidine (cas: 17573-78-3SDS of cas: 17573-78-3).
4,5,6-Trifluoropyrimidine (cas: 17573-78-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.SDS of cas: 17573-78-3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia