Synthesis of Benzazolyl Pyrimidines Under Ultrasonication and Their Antimicrobial Activity was written by Kayathi, Narendra Babu;Sowmya, Donthamsetty V.;Adivireddy, Padmaja;Venkatapuram, Padmavathi. And the article was included in Journal of Heterocyclic Chemistry in 2018.Related Products of 40230-24-8 This article mentions the following:
The benzoxazolyl/benzothiazolyl/benzimidazolyl pyrimidines were prepared under ultrasonication in the presence of pyridine/dimethylaminopyridine and triethylamine. Better yields were recorded in 4-(N,N-dimethylamino)pyridine and Et3N. The presence of electron withdrawing chloro, bromo, and nitro substituents enhanced antimicrobial activity (N-(benzo[d]thiazol-2-ylmethyl)-4,6-bis(4-chlorophenyl) pyrimidin-2-amine, N-(benzo[d]thiazol-2-ylmethyl)-4,6-bis(4-nitrophenyl) pyrimidin-2-amine, N-((1H-benzo[d]imidazol-2-yl)methyl)-4,6-bis(4-nitrophenyl)pyrimidin-2-amine: min. inhibitory concentration = 6.25 μg/well against Bacillus subtilis; N-(benzo[d]thiazol-2-ylmethyl)-4,6-bis(4-nitrophenyl) pyrimidin-2-amine, N-((1H-benzo[d]imidazol-2-yl)methyl)-4,6-bis(4-nitrophenyl)pyrimidin-2-amine: min. inhibitory concentration = 6.25 μg/well against Aspergillus niger). In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 40230-24-8
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia