Studies of pyrimidine derivatives. XXXVIII. Cross-coupling reaction of N-heteroaryl iodides with ethoxycarbonylmethylzinc bromide in the presence of palladium catalyst was written by Yamanaka, Hiroshi;Annaka, Masayuki;Kondo, Yoshinori;Sakamoto, Takao. And the article was included in Chemical & Pharmaceutical Bulletin in 1985.Recommanded Product: 2-Bromo-4,6-dimethylpyrimidine This article mentions the following:
In the presence of tetrakis(triphenylphosphine)palladium, 2-iodo-4,6-dimethylpyrimidine and 4-iodo-2,6-dimethylpyrimidine reacted with ethoxycarbonylmethylzinc bromide (Reformatskii reagent) to give Et 4,6-dimethyl-2-pyrimidineacetate and Et 2,6-dimethyl-4-pyrimidineacetate, resp. In contrast, the reaction of 5-iodo-2,4-dimethylpyrimidine with the same reagent resulted in recovery of the starting iodide. Similar results were observed in the reactions of various N-heteroaryl iodides. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Recommanded Product: 2-Bromo-4,6-dimethylpyrimidine).
2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 2-Bromo-4,6-dimethylpyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia