Bai, Song et al. published their research in Heterocycles in 2018 | CAS: 165807-05-6

4-Dimethoxymethylpyrimidin-2-ylamine (cas: 165807-05-6) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Electric Literature of C7H11N3O2

Cinchona alkaloid thiourea-catalyzed one-pot synthesis and bioselective activities of β-amino acid ester derivatives containing a pyrimidine moiety was written by Bai, Song;Liu, Shan;Zhu, Yunying;Wei, Xian;Zhao, Kunhong;Li, Weihua;Wu, Qin. And the article was included in Heterocycles in 2018.Electric Literature of C7H11N3O2 This article mentions the following:

Both enantiomers of β-amino acid ester derivatives I (R1 = cyclohexyl, Ph, 4-ClC6H4, 4-MeC6H4, 4-MeOC6H4, 2-furyl; R2 = Me, Et) that contain a pyrimidine moiety were produced from 2-amino-4-(dimethoxymethyl)pyrimidine, aldehydes R1CHO and malonates H2C(CO2R2)2 in an enantioselective Mannich-type one-pot reaction in good yields and with excellent enantiomeric excess (up to >99% ee) using chiral cinchona alkaloid thiourea catalysts. An evaluation of the antiviral activities of reaction products against tobacco mosaic virus (TMV) was promising with high and selective biol. activities. Compound (-)-I (R1 = 2-furyl; R2 = Me) showed an excellent anti-TMV activity (curative activity, 56.1%; inactivation activity, 70.7%; protection activity, 95.7%) at 500 μg/mL. These values exceeded those of the com. available antiviral agent, ningnanmycin (curative activity, 52.6%; inactivation activity, 62.0%; protection activity, 90.2%). These novel chiral compounds were used as protective agents against TMV disease. In the experiment, the researchers used many compounds, for example, 4-Dimethoxymethylpyrimidin-2-ylamine (cas: 165807-05-6Electric Literature of C7H11N3O2).

4-Dimethoxymethylpyrimidin-2-ylamine (cas: 165807-05-6) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Electric Literature of C7H11N3O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia