Electric Literature of 39906-04-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine. A new synthetic method of this compound is introduced below.
1- 7A-80) a 4, 6-Dichloro-2-methylpyrimidin-5-ylamine (100 mg, 0.56 MMOL) and 4-chlorophenylamine (86 mg, 0.68 MMOL) were combined in H20 (1.5 ml) and 10: 1 ethanol/HCI (0.24 ml) and heated to reflux for 6 h. The reaction mixture was cooled and H20 added to it. The product was collected by filtration and dried on high vacuum to give the desired compound 1- 7A-80) a as a tan solid (173 mg) that was carried on crude: +ESI MS (M+1) 269.2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/37823; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia