In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one, the common compound, a new synthetic route is introduced below. Formula: C4H5N3O2
General procedure: Typically, 2-aminopyrimidine-4,6-diol (1a, 0.5 mmol, 1.0 equiv)/2-methylpyrimidine-4,6-diol (1b, 0.5 mmol, 1.0 equiv), nitroolefins (2, 0.5 mmol, 1.0 equiv), as well as water (2.5 mL) were introduced into a 10 mL reaction vial. Then, the reaction vial was closed and stirred for given time at 90 C. Upon completion, the reaction mixture was cooled to room temperature and diluted with cold water (30 mL). The solid product was collected by filtration and was purified by recrystallization from hot 95% EtOH to afford the goal product 5-arylfuro[2,3-d]pyrimidin-4-ol (3) as off-white to yellow solid. 2-Amino-6-methyl-5-phenylfuro[2,3-d]pyrimidin-4-ol (3a) Light yellow solid; Mp: >300 C; 1H NMR (400 MHz, DMSO-d6): delta = 10.82 (br, s, 1H, OH), 7.50 (d, J = 7.2 Hz, 2H, ArH), 7.39 (t, J = 7.6 Hz, 2H, ArH), 7.28-7.31 (m, 1H, ArH), 6.63 (br, s, 2H, NH2), 2.32 (s, 3H, CH3); 13C NMR (100 MHz, DMSO-d6): delta = 167.3, 158.9, 154.3, 143.0, 131.9, 130.0, 128.2, 127.1, 117.7, 96.4, 12.6; HRMS (ESI): m/z [M+H]+ calcd for C13H12N3O2 + : 242.0924; found: 242.0929.
The synthetic route of 56-09-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Li, Chunmei; Zhang, Furen; Tetrahedron Letters; vol. 58; 16; (2017); p. 1572 – 1575;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia