Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5909-24-0, name is Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate. A new synthetic method of this compound is introduced below., Application In Synthesis of Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate
To 600ml of methylene dichloride was added lOOg of ethyl 4-chloro-2-(methylsulfanyl) pyrimidine-5-carboxylate and 91.2g of 3-chloro-4-methoxybenzylamine. The reaction mixture was stirred and 500m1 of water, 48g of sodium carbonate and Ig of tetra-butylammonium bromide were added to it. The reaction mixture was then maintained overnight at 25-30C. After completion of reaction, methylene dichloride layer was separated, washed with water and evaporated to obtain 145g of ethyl 4-[(3-chloro-4-methoxybenzyl) amino]-2-(methyl sulfanyl) pyrimidine-5-carboxylate having 95% of HPLC purity.
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Reference:
Patent; WANBURY LTD.; NITIN SHARADCHANDRA PRADHAN; VIHAR RAGHUNATH TELANGE; SURYAKANT SHIVAJI POL; SHASHIKANT BALU PADWAL; NITN SHANKAR BONDRE; WO2015/177807; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
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