Adding a certain compound to certain chemical reactions, such as: 933702-55-7, 2-Chloropyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 933702-55-7, blongs to pyrimidines compound. Application In Synthesis of 2-Chloropyrimidine-5-carbaldehyde
To a solution of 2-chloropyrirnidine-5-carbaldehyde (0.30 g, 2.11 mmol) in THE (10 mL) was added intermediate 74 (0.36 g, 1.75 mmoi) and the reaction mixture was stirred at ambient temperature for 1 h. To the resulting solution was added sodium cyanoborohydride (0.27 g, 4.38 mmoi) and MeOH (mu.) and stirring was continued for 14 h. The reaction mixture was dilutedwith water (20 mL) and extracted with 7% MeOH:DCM (3 x 30 mL), The combined organic layers were dried over anhydrous sodium sulfate and evaporated under reduced pressure. The residue was triturated with DCM/n-hexane to obtain Intermediate 98 (0.45 g, 43.00%), ?Fl NMR (400 MHz, DMSO-d6) ppm 2.23 (s, 3 H), 2.59-2.67 (rn, 2 H), 3.17 (d, J 4.16 Hz, I H), 3.80 (s, I H), 4.57 (d, J= 4.65 Hz, I H), 5.01 (d, J= 3.67 Hz, I H), 5.38 (d, J= 3.42 Hz, 2El), 5.48 – 5.62 (m, I H). 7.56 – 7.74 (m, 2 H). 8.64 – 8.76 (m, 2 H). LCMS (Aithod-O): retention time 0.72 mm, [M+H1 334.5
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,933702-55-7, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; PANDA, Manoranjan; YADAV, Navnath Dnyanoba; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (321 pag.)WO2018/93569; (2018); A1;,
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