Analyzing the synthesis route of 18740-38-0

At the same time, in my other blogs, there are other synthetic methods of this type of compound,18740-38-0, Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.18740-38-0, name is Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, molecular formula is C6H4N2O2S, molecular weight is 168.1732, as common compound, the synthetic route is as follows.Recommanded Product: Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

3 g (0.018 mol) of the intermediate lib was placed in a 100 mL three-necked flask,30 mL (0.329 mol) of phosphorus oxychloride was slowly added dropwise,After 30 min addition, 2 drops of DMF were added to the reaction mixture and the reaction was heated to reflux for 8 h. The reaction was poured into 1000 g of ice water with stirring, and a large amount of orange-colored solid was precipitated. The filter cake was washed with a large amount of water and dried at 45 C for 24 hours to obtain 1.8 g of an orange solid in a yield of 49%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,18740-38-0, Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; Jiangxi science and technology Normal University; Zhu, wufu; Zheng, PengWu; Chen, Chen; Xu, Yuan; Sun, chengyu; Wu, Chunjiang; Tu, Qidong; (22 pag.)CN103980287; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia