Extracurricular laboratory: Synthetic route of 157335-93-8

The synthetic route of 157335-93-8 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 157335-93-8 , The common heterocyclic compound, 157335-93-8, name is 4,6-Dimethylpyrimidine-5-carboxylic acid, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLES; Example 1: Preparation of 1-(2,4-dimethylpyrimidine-5-carbonyl)-4- piperidone – Compound IV:; To a suspension solution of 90.0 g of 4,6-dimethylpyrimidine-5- carboxylic acid (I) and a catalytic amount of dimethylformamide (0.45 ml_) in CH3CN (630 ml_) was slowly added oxalyl chloride (78.8 g) at -50C to 50C. The reaction was then aged at O0C for 2 hours. EPO In a separate flask, a heterogeneous mixture of K3PO4 (136.1 g), K2HPO4 (205.9 g) in water (270 ml_) and CH3CN (540 ml_) at O0C was added to a solution of 99.8 g of 4-piperidone monohydrate hydrochloride (III) in water (135 ml_). The reaction mixture was agitated at O0C for 2 hours.

The synthetic route of 157335-93-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2006/74264; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia