In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione, the common compound, a new synthetic route is introduced below. SDS of cas: 2434-53-9
General procedure: A mixture of isatin (0.147 g, 1 mmol), acetophenone (0.09 mL, 1.5 mmol), and piperidine (two drops, 0.1 mmol) in ethanol (95.5%, 1 mL) was heated at 80 C for about 5 min. To the solid obtained at this stage was added 6-amino-1,3-dimethyluracil (0.155 g, 1 mmol), p-toluenesulfonic acid monohydrate (0.076 g, 0.04 mmol), and EtOH (95.5%, 2 mL). The mixture was stirred and heated gently at 80 C. After completion of the reaction (115 min), as monitored by TLC using 5:1 ratio of ethyl acetate/n-hexane, the reaction mixture was cooled to room temperature and then filtered. The separated solids were washed twice with 10 mL of water and 3 mL of hot ethanol (95.5%) to obtain the pure product 4a.
The synthetic route of 2434-53-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Rad-Moghadam, Kurosh; Azimi, Seyyedeh Cobra; Tetrahedron; vol. 68; 47; (2012); p. 9706 – 9712;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia